![]() ![]() However, patients who experience more severe attacks and relapsing MOGAD are at risk for more severe deficits. Complete recovery from the onset attack is common in children, and in general the outcome is favorable. Most patients respond well to intravenous steroids, with some also requiring oral prednisone for one to four weeks. ![]() Disease modifying therapies (DMTs) including therapies for children with relapsing forms of MOGAD.2018 1:66–72.At the Neuroscience Center, our goal is to stop symptoms and restore a child's normal growth and development with as few treatment-related side effects as possible. MOG antibody disease: a review of MOG antibody seropositive neuromyelitis optica spectrum disorder. Narayan R, Simpson A, Fritsche K, Salama S, Pardo S, Mealy M, et al. Clinical and imaging features of children with autoimmune encephalitis and MOG antibodies. Wegener‐Panzer A, Cleaveland R, Wendel E‐M, Baumann M, Bertolini A, Häusler M, et al. International multicenter examination of MOG antibody assays. Reindl M, Schanda K, Woodhall M, Tea F, Ramanathan S, Sagen J, et al. Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Does MOG Ig‐positive AQP4‐seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder? Neurol Neuroimmunol Neuroinflamm. Chien has received speaking fees from Bayer and research support from Novartis unrelated to this review. ![]() His research is funded by the German Ministry for Education and Research (BMBF), Deutsche Forschungsgemeinschaft (DFG), Einstein Foundation, Guthy Jackson Charitable Foundation, EU FP7 Framework Program, Biogen, Genzyme, Merck Serono, Novartis, Bayer, Alexion, Roche, Parexel and Almirall. Paul is named as co‐inventor on the patent application for the foveal shape analysis method (‘Method for estimating shape parameters of the fovea byoptical coherence tomography’, International Publication number: ‘WO 2019/016319 A1’), is a co‐founder and holds shares in technology start‐up Nocturne GmbH, receives honoraria for lecturing and travel expenses for attending meetings from Guthy Jackson Foundation, Bayer, Biogen, Merck Serono, Sanofi Genzyme, Novartis, Alexion, Viela Bio, Roche, UCB, Mitsubishi Tanabe and Celgene. ![]() Finke receives research funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation grant numbers FI 2309/1‐1 and FI 2309/2‐1) and the German Ministry of Education and Research (BMBF, grant number 01GM1908D CONNECT‐GENERATE) unrelated to this review. Oertel receives research support from the American Academy of Neurology (AAN) unrelated to this review. Bartels is supported by the Berlin Institute of Health (BIH) and the Berlin School of Mind and Brain, both unrelated to this review. Clinical & Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology.į. Magnetic resonance imaging myelin oligodendrocyte glycoprotein associated disorders optical coherence tomography. We describe how these imaging techniques may be used to study this group of disorders and discuss how image analysis methods have led to recent insights for consideration in future studies. In this review, we discuss key clinical and neuroimaging characteristics of paediatric and adult MOGAD. In-vivo imaging of the MOGAD patient central nervous system has shown some distinguishing features when evaluating magnetic resonance imaging of the brain, spinal cord and optic nerves, as well as retinal imaging using optical coherence tomography. Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are rare in both children and adults, and have been recently suggested to be an autoimmune neuroinflammatory group of disorders that are different from aquaporin-4 autoantibody-associated neuromyelitis optica spectrum disorder and from classic multiple sclerosis. 5 Department for Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.4 NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.3 Humboldt-Universität zu Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Experimental and Clinical Research Center, Charité -Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin, Germany.2 Berlin School of Mind and Brain, Berlin Institute of Health at Charité - Universitätsmedizin Berlin and, Humboldt-Universität zu Berlin, Berlin, Germany.1 Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ![]()
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